BioTech Encyclopedia

Silk fibroin: uses in research

Also: regenerated silk, Bombyx mori fibroin

Silk fibroin is the structural protein of silkworm silk. Once the sticky sericin coating is removed, it can be dissolved in water and reshaped into films, gels, sponges, fibres and printed parts. Entries summarise reported research; biomedical entries are descriptive only, not medical advice.

Readiness: lab lab studies · prototype demonstrated objects · commercial products or buildings in real use · review summaries of other studies.

3D printing

lab 3D printing 2018

Light-curable silk bio-ink

Developed a silk fibroin ink that can be shaped precisely by light-based (DLP) 3D printing.

Built / tested: printed hydrogel structures

As reported in: Kim, Yeon, Lee et al. (2018). Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing. Nature Communications. doi:10.1038/s41467-018-03759-y

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biomedical research

lab biomedical research 2005

Water-processed porous silk scaffolds

Made porous 3D silk sponges using a water-based process, as scaffolds for tissue research (descriptive only).

Built / tested: porous scaffolds

As reported in: Kim, Park, Joo Kim et al. (2005). Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin. Biomaterials. doi:10.1016/j.biomaterials.2004.07.044

Abstract only

electronics

prototype electronics 2010

Dissolvable silk films carrying ultrathin electronics

Used thin silk films as a dissolvable backing that lets very thin electronics conform to soft, curved surfaces.

Built / tested: conformal electrode arrays

As reported in: Kim, Viventi, Amsden et al. (2010). Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature Materials. doi:10.1038/nmat2745

Read free · preprint / author manuscript

insulation

lab insulation 2018

Fire-retardant insulating silk aerogels

Made hybrid aerogels by self-assembling silk fibroin inside a silica network, reported as compressible, heat-insulating and fire-retardant, with a route towards 3D printing.

Built / tested: silk–silica hybrid aerogels

As reported in: Maleki, Montes, Hayati-Roodbari et al. (2018). Compressible, Thermally Insulating, and Fire Retardant Aerogels through Self-Assembling Silk Fibroin Biopolymers Inside a Silica Structure—An Approach towards 3D Printing of Aerogels. ACS Applied Materials & Interfaces. doi:10.1021/acsami.8b05856

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materials science

lab materials science 2011

A lab protocol for making silk materials

A step-by-step protocol for turning silkworm cocoons into fibroin solution and then into many material formats.

Built / tested: films, gels, sponges, fibres

As reported in: Rockwood, Preda, Yücel et al. (2011). Materials fabrication from Bombyx mori silk fibroin. Nature Protocols. doi:10.1038/nprot.2011.379

Read free · preprint / author manuscript

review materials science 2015

Structure and mechanics of silk materials

A review linking the molecular structure of silk fibroin to its mechanical behaviour and uses.

As reported in: Koh, Cheng, Teng et al. (2015). Structures, mechanical properties and applications of silk fibroin materials. Progress in Polymer Science. doi:10.1016/j.progpolymsci.2015.02.001

Abstract only

textiles

review textiles 2021

Smart silk fibres for textile electronics and photonics

Reviews functionalised silk fibres built into textiles that sense, conduct or handle light.

As reported in: Wu, Ma, Liu (2021). From Mesoscopic Functionalization of Silk Fibroin to Smart Fiber Devices for Textile Electronics and Photonics. Advanced Science. doi:10.1002/advs.202103981

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