Also: halicin, abaucin, machine learning
Neural networks screening millions of molecules for new antibiotics.
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Stokes and colleagues trained a deep neural network that identified halicin, structurally unlike known antibiotics, which killed a wide range of pathogens and treated C. difficile and pan-resistant A. baumannii infections in mice.
Publisher update notice: erratum
As reported in: Stokes, Yang, Swanson et al. (2020). A Deep Learning Approach to Antibiotic Discovery. Cell. doi:10.1016/j.cell.2020.01.021
Liu and colleagues used a neural network to find abaucin, a narrow-spectrum antibiotic against Acinetobacter baumannii that disrupts lipoprotein trafficking.
As reported in: Liu, Catacutan, Rathod et al. (2023). Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii. Nature Chemical Biology. doi:10.1038/s41589-023-01349-8
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