BioTech Encyclopedia

Axolotl limb regeneration

Regeneration: basic research on living systems, not technology.

Also: Ambystoma mexicanum, salamander

The Mexican axolotl salamander can regrow whole limbs.

Known properties: Axolotl limb regeneration

Only what the cited papers report.

Key measured values

Values as stated in the cited paper's abstract.

PropertyValueSource
Genome size32 gigabase pairsNowoshilow 2018

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Timeline

  1. 2009 Cells remember where they came from
  2. 2018 The giant axolotl genome

Readiness: lab lab studies · prototype demonstrated objects · commercial products or buildings in real use · review summaries of other studies.
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lab biology 2009

Cells remember where they came from

Kragl and colleagues tracked GFP-labelled cells and found each limb tissue makes progenitors with restricted potential, so limbs regrow without cells becoming fully pluripotent.

As reported in: Kragl, Knapp, Nacu et al. (2009). Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature. doi:10.1038/nature08152

Abstract only

lab biology 2018

The giant axolotl genome

Nowoshilow and colleagues assembled the 32-gigabase axolotl genome and found evidence that species-restricted genes may contribute to limb regeneration.

Publisher update notice: correction

As reported in: Nowoshilow, Schloissnig, Fei et al. (2018). The axolotl genome and the evolution of key tissue formation regulators. Nature. doi:10.1038/nature25458

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