Also: Dolly, somatic cell nuclear transfer, SCNT, cloned mammals
Cloning by nuclear transfer puts the nucleus of a body cell into an egg cell. Dolly the sheep (born 1996, reported 1997) was the first mammal cloned from an adult cell. Later work cloned mice and monkeys.
Readiness: lab lab studies · prototype demonstrated objects · commercial products or buildings in real use · review summaries of other studies.
Campbell and colleagues cloned sheep (Megan and Morag) by nuclear transfer from a cultured cell line.
Built / tested: cloned sheep
As reported in: Campbell, McWhir, Ritchie et al. (1996). Sheep cloned by nuclear transfer from a cultured cell line. Nature. doi:10.1038/380064a0
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Wilmut and colleagues reported lambs from fetal and adult cells, including Dolly, cloned from an adult mammary cell.
Built / tested: Dolly the sheep
As reported in: Wilmut, Schnieke, McWhir et al. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature. doi:10.1038/385810a0
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Wakayama and colleagues produced full-term cloned mice from cumulus cell nuclei.
Built / tested: cloned mice
As reported in: Wakayama, Perry, Zuccotti et al. (1998). Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature. doi:10.1038/28615
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Liu and colleagues cloned macaques (Zhong Zhong and Hua Hua) by somatic cell nuclear transfer.
Built / tested: cloned monkeys
As reported in: Liu, Cai, Wang et al. (2018). Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. Cell. doi:10.1016/j.cell.2018.01.020
Schnieke and colleagues produced cloned sheep carrying a human clotting factor IX gene.
Built / tested: transgenic cloned sheep
As reported in: Schnieke, Kind, Ritchie et al. (1997). Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts. Science. doi:10.1126/science.278.5346.2130
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