Also: H2S, CO, gasotransmitters, CORMs
Like nitric oxide, small amounts of hydrogen sulfide and carbon monoxide act as signals in the body. Both are toxic in larger amounts.
Readiness: lab lab studies · prototype demonstrated objects · commercial products or buildings in real use · review summaries of other studies.
Abe and Kimura proposed hydrogen sulfide as a natural signaling molecule in the brain.
As reported in: Abe, Kimura (1996). The possible role of hydrogen sulfide as an endogenous neuromodulator. The Journal of Neuroscience. doi:10.1523/JNEUROSCI.16-03-01066.1996
Yang and colleagues showed mice lacking the H2S-making enzyme CSE had high blood pressure.
As reported in: Yang, Wu, Jiang et al. (2008). H <sub>2</sub> S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase. Science. doi:10.1126/science.1162667
Blackstone, Morrison, and Roth found H2S put mice into a reversible suspended-animation-like state.
As reported in: Blackstone, Morrison, Roth (2005). H <sub>2</sub> S Induces a Suspended Animation-Like State in Mice. Science. doi:10.1126/science.1108581
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Otterbein and colleagues found low-dose carbon monoxide had anti-inflammatory effects.
As reported in: Otterbein, Bach, Alam et al. (2000). Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature Medicine. doi:10.1038/74680
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Motterlini and colleagues introduced molecules that deliver small amounts of CO.
As reported in: Motterlini, Clark, Foresti et al. (2002). Carbon Monoxide-Releasing Molecules. Circulation Research. doi:10.1161/hh0202.104530
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Motterlini and Otterbein reviewed the therapeutic potential of carbon monoxide.
As reported in: Motterlini, Otterbein (2010). The therapeutic potential of carbon monoxide. Nature Reviews Drug Discovery. doi:10.1038/nrd3228
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