BioTech Encyclopedia

Lab-grown & artificial skin: uses in research

Also: tissue-engineered skin, Integra, cultured epidermis

Burn and wound patients have been treated with artificial skin scaffolds and with sheets of skin cells grown in the lab, including genetically corrected skin.

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Timeline

  1. 1981 Artificial skin for burns
  2. 2017 Whole epidermis from gene-corrected stem cells

Readiness: lab lab studies · prototype demonstrated objects · commercial products or buildings in real use · review summaries of other studies.
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commercial biomedical 1981

Artificial skin for burns

Burke, Yannas and colleagues successfully used a collagen-based artificial skin on patients with extensive burns.

Built / tested: artificial dermis

As reported in: BURKE, YANNAS, QUINBY et al. (1981). Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn Injury. Annals of Surgery. doi:10.1097/00000658-198110000-00005

Read free · preprint / author manuscript

prototype biomedical 2017

Whole epidermis from gene-corrected stem cells

Hirsch and colleagues regrew most of a boy's skin using genetically corrected stem cells for the blistering disease epidermolysis bullosa.

Built / tested: transgenic epidermis grafts

As reported in: Hirsch, Rothoeft, Teig et al. (2017). Regeneration of the entire human epidermis using transgenic stem cells. Nature. doi:10.1038/nature24487

Read free · preprint / author manuscript