Also: cryo-EM, electron cryo-microscopy
Microscopes that use electrons instead of light; frozen-sample cryo-EM now reveals biomolecules near atomic detail.
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Kühlbrandt described how new detectors and image processing are giving high-resolution cryo-EM structures of biomolecules.
As reported in: Kühlbrandt (2014). The Resolution Revolution. Science. doi:10.1126/science.1251652
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Henderson and colleagues built a model of bacteriorhodopsin from high-resolution electron cryo-microscopy.
As reported in: Henderson, Baldwin, Ceska et al. (1990). Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. Journal of Molecular Biology. doi:10.1016/S0022-2836(05)80271-2
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