In 2000, two landmark papers showed that genes could be wired together like electronic parts, giving bacteria a memory switch and a ticking clock. They are often seen as the start of synthetic biology.
Known properties: Synthetic gene circuits
Only what the cited papers report.
The repressilator used green fluorescent protein as a readout of its state in individual cells. doi:10.1038/35002125
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Gardner, Cantor and Collins built a synthetic two-state (bistable) gene network in E. coli that flips between states and stays there, and gave a simple theory predicting when this works.
Built / tested: genetic toggle switch
As reported in: Gardner, Cantor, Collins (2000). Construction of a genetic toggle switch in Escherichia coli. Nature. doi:10.1038/35002131
Elowitz and Leibler wired three repressor genes not from any natural clock into a loop in E. coli, making cells periodically switch green fluorescent protein on and off.
Built / tested: repressilator
As reported in: Elowitz, Leibler (2000). A synthetic oscillatory network of transcriptional regulators. Nature. doi:10.1038/35002125